Exploring the Link Between Dopamine and Parkinson’s Disease

Abstract

The review claims that there is a relationship between dopamine and Parkinson’s disease. Parkinson’s disease is a progressive neurological disorder that results in the loss of motor and non-motor functions due to neurodegeneration in different parts of the brain. It is important to un- derstand the key molecular pathogenic mechanisms behind Parkinson’s disease including alpha-synuclein misfolding, mitochondrial dysfunction, and oxidative stress in order to bring an insightful approach to the second most common neurological disease among the society. Other than that, in order to justify the motor and non-motor symptoms of the disease, un- derstanding the role of dopamine as a chemical messenger that regulates some motor and non-motor functions of the brain is crucial. Herewith, the missing parts in the relationship between dopamine-producing neurons and Parkinson’s disease will be unrevealed, and sustainable therapeutic approaches can be determined.