Base Editing: Advancements and the Future of Gene Therapy

Abstract

The work done on CRISPR-Cas9 has pioneered the way for base editing, a technology that utilizes RNA-guided nucleases and other components of CRISPR systems along with a specific deaminase that can convert a C base to a T base, or a G to an A. Base editing focuses particularly on converting point mutations, which lead to the majority of human genetically linked diseases. After the conversion from a problematic gene, the DNA sequence is changed, effectively changing the genome’s identity. This research paper focuses on advantages and current applications of base editing using laboratory based and therapeutics based research, along with highlighting current drawbacks and future theoretical applications of the technology